Do non-bleeding, critically ill patients with thrombocytopenia undergoing lumbar puncture require prophylactic platelet transfusion? |
The ACCP 2025 guidelines suggest administering platelets in critically ill patients at high risk of bleeding due to thrombocytopenia undergoing lumbar puncture if platelet counts are ≤40-50×10⁹/L...
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What is the latest evidence on male partner treatment for preventing bacterial vaginosis recurrence in women? |
The 2025 StepUp study demonstrated that treating male partners with combined oral and topical antimicrobials significantly reduced BV recurrence in women within 12... |
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What did the recent three-arm BASIL-3 RCT find for femoropopliteal revascularization in patients with chronic limb-threatening ischemia? |
The BASIL-3 RCT suggests that in patients with CLTI requiring endovascular femoropopliteal revascularization, there is no significant difference in amputation-free... |
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What are the treatment options for low-risk anal margin or anal canal cancer? |
For low-risk anal margin or anal canal cancer, treatment options include local excision, topical therapies, and radiation therapy, depending on the tumor size and location... |
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Should patients with asymptomatic histoplasmosis receive treatment? |
In immunocompetent patients, treatment is generally not recommended for asymptomatic histoplasmosis. In certain immunocompromised patients... |
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Is daratumumab monotherapy effective for smoldering myeloma? |
Daratumumab monotherapy has shown effectiveness in delaying disease progression in high-risk smoldering multiple myeloma, as demonstrated by the AQUILA study... |
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What is the evidence for asundexian use in atrial fibrillation? |
Asundexian is an oral factor XIa inhibitor that works by selectively inhibiting factor XIa, reducing thrombin generation and clot formation. The OCEANIC-AF study found that asundexian was inferior to apixaban in preventing stroke or systemic embolism... |
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What is the role of high-dose vitamin D supplementation in multiple sclerosis? |
High-dose vitamin D has been associated with a decrease in disease activity in patients with clinically isolated syndrome typical for MS, as shown in the D-Lay MS study... |
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Compare livedo racemosa and livedo reticularis in a table. |
Livedo racemosa and livedo reticularis are both vascular skin patterns, but they differ in appearance and underlying causes... |
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